Mapping of native inorganic elements and injected nanoparticles in a biological organ with laser-induced plasma
Emission spectroscopy of laser-induced plasma from a thin section of mouse kidney successfully detected inorganic elements, Na, Ca, Cu, and Gd, naturally contained in the organ or artificially injected in the form of Gd-based nanoparticle. A two-dimensional scan of the sample allowed the laser beam...
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Veröffentlicht in: | Applied physics letters 2012-11, Vol.101 (22) |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Emission spectroscopy of laser-induced plasma from a thin section of mouse kidney successfully detected inorganic elements, Na, Ca, Cu, and Gd, naturally contained in the organ or artificially injected in the form of Gd-based nanoparticle. A two-dimensional scan of the sample allowed the laser beam to explore its surface with a resolution of 100 μm, resulting in a quantitative elemental mapping of the organ with sub-mM sensitivity. The compatibility of the setup with standard optical microscopy emphasizes the potential to provide multiple images of a same biological tissue with different types of response which can be elemental, molecular, or cellular. |
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ISSN: | 0003-6951 1077-3118 |
DOI: | 10.1063/1.4768777 |