Fast acoustic tweezers for the two-dimensional manipulation of individual particles in microfluidic channels

This paper presents a microfluidic device that implements standing surface acoustic waves in order to handle single cells, droplets, and generally particles. The particles are moved in a very controlled manner by the two-dimensional drifting of a standing wave array, using a slight frequency modulat...

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Veröffentlicht in:Applied physics letters 2012-09, Vol.101 (11)
Hauptverfasser: Tran, S. B. Q., Marmottant, P., Thibault, P.
Format: Artikel
Sprache:eng
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Zusammenfassung:This paper presents a microfluidic device that implements standing surface acoustic waves in order to handle single cells, droplets, and generally particles. The particles are moved in a very controlled manner by the two-dimensional drifting of a standing wave array, using a slight frequency modulation of two ultrasound emitters around their resonance. These acoustic tweezers allow any type of motion at velocities up to few ×10 mm/s, while the device transparency is adapted for optical studies. The possibility of automation provides a critical step in the development of lab-on-a-chip cell sorters and it should find applications in biology, chemistry, and engineering domains.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.4751348