Pharmaceuticals Perspectives of High Pressure: A Soft Tool for Sterilization of Fragile Drugs

Pharmaceuticals Perspectives of High Pressure: A Soft Tool for Sterilization of Fragile Drugs

In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min at 400 MPa) inactivates totally pure suspensions of P. aeruginosa and C. albi...

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Veröffentlicht in:Diffusion and defect data. Solid state data. Pt. A, Defect and diffusion forum Defect and diffusion forum, 2002-01, Vol.208-209, p.55-58
Hauptverfasser: Larrouture, D., Largeteau, A., Demazeau, Gérard, Rigaldie, Y., Lemagnen, G., Abba, M., Haller, R., Grislain, L.
Format: Artikel
Sprache:eng
Schlagworte:
Chemical and Process Engineering
Engineering Sciences
Life Sciences
Pharmaceutical sciences
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Zusammenfassung:In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min at 400 MPa) inactivates totally pure suspensions of P. aeruginosa and C. albicans. HHP at low temperature induces a stronger inactivation than at room temperature. S. aureus needs a longer HHP duration treatment or a multi-step treatment to be totally inactivated. But same tests applied to B. subtilis did not lead to a total inactivation; furtherprocesses are in progress in order to cause spores of B. subtilis to germinate
ISSN:1012-0386
1662-9507
1662-9507
DOI:10.4028/www.scientific.net/DDF.208-209.55