Self-Assembling Peptide-Based Nanoparticles for siRNA Delivery in Primary Cell Lines

Self-Assembling Peptide-Based Nanoparticles for siRNA Delivery in Primary Cell Lines

The secondary amphipathic peptide CADY forms stable positively charged nanoparticles with short interfering RNA (siRNA), which involves both electrostatic and hydrophobic interactions. CADY/siRNA self‐assembling nanoparticles adopt a “raspberry”‐like architecture cemented together by a matrix of fre...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2012-07, Vol.8 (14), p.2184-2188
Hauptverfasser: Deshayes, Sébastien, Konate, Karidia, Rydström, Anna, Crombez, Laurence, Godefroy, Cédric, Milhiet, Pierre-Emmanuel, Thomas, Annick, Brasseur, Robert, Aldrian, Gudrun, Heitz, Frédéric, Muñoz-Morris, Maria A., Devoisselle, Jean-Marie, Divita, Gilles
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biochemistry, Molecular Biology
Cell Line
Cell Membrane Permeability
Cell-Penetrating Peptides - chemistry
Drug Carriers - chemistry
drug delivery
Humans
Jurkat Cells
Life Sciences
nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
peptides
Peptides - chemistry
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - chemistry
self-assembly
siRNA
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Beschreibung
Zusammenfassung:The secondary amphipathic peptide CADY forms stable positively charged nanoparticles with short interfering RNA (siRNA), which involves both electrostatic and hydrophobic interactions. CADY/siRNA self‐assembling nanoparticles adopt a “raspberry”‐like architecture cemented together by a matrix of free peptides. These nanoparticles are nontoxic and promote efficient delivery of siRNA in challenging primary cell lines.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201102413