Mechanisms and Synthetic Modulators of AHL-Dependent Gene Regulation

Mechanisms and Synthetic Modulators of AHL-Dependent Gene Regulation

Many different proteobacteria use a LuxR-acylated homoserine lactone (AHL) based quorum sensing (QS) system to control gene expression in response to population density. The key elements essential for LuxR-AHL QS are examined. Tte LuxR protein family is also explored in the context of its two-domain...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical reviews 2011-01, Vol.111 (1), p.4-27
Hauptverfasser: Stevens, Ann M, Queneau, Yves, Soulère, Laurent, Bodman, Susanne von, Doutheau, Alain
Format: Artikel
Sprache:eng
Schlagworte:
Acyl-Butyrolactones - chemistry
Acyl-Butyrolactones - metabolism
Bacteria - metabolism
Chemical Sciences
Control systems
Detection
Gene expression
Gene Expression Regulation, Bacterial
Lactones
Microbiology
Microorganisms
Modulators
Organic chemistry
Population density
Protein Structure, Tertiary
Proteins
Quorum Sensing - drug effects
Repressor Proteins - antagonists & inhibitors
Repressor Proteins - metabolism
Signal transduction
Trans-Activators - antagonists & inhibitors
Trans-Activators - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Many different proteobacteria use a LuxR-acylated homoserine lactone (AHL) based quorum sensing (QS) system to control gene expression in response to population density. The key elements essential for LuxR-AHL QS are examined. Tte LuxR protein family is also explored in the context of its two-domain structure.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr100064s