Diastereo- and Enantioselective Intramolecular C(sp3)H Arylation for the Synthesis of Fused Cyclopentanes

Diastereo- and Enantioselective Intramolecular C(sp3)H Arylation for the Synthesis of Fused Cyclopentanes

All CH bonds are not equal: The intramolecular arylation of unactivated C(sp3)H bonds in the presence of a chiral Pd/binepine catalyst allows the synthesis of fused cyclopentanes efficiently and in an diastereo‐ and enantioselective manner (see scheme).

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Veröffentlicht in:Chemistry : a European journal 2012-04, Vol.18 (15), p.4480-4484
Hauptverfasser: Martin, Nicolas, Pierre, Cathleen, Davi, Michaël, Jazzar, Rodolphe, Baudoin, Olivier
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
Catalysts
Chemical Sciences
Chemistry
CC coupling
CH activation
Organic chemistry
Palladium
Synthesis
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Beschreibung
Zusammenfassung:All CH bonds are not equal: The intramolecular arylation of unactivated C(sp3)H bonds in the presence of a chiral Pd/binepine catalyst allows the synthesis of fused cyclopentanes efficiently and in an diastereo‐ and enantioselective manner (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201200018