NK cell MHC class I specific receptors (KIR): from biology to clinical intervention

Highlights ► NK cell activity is governed by balance of activating and inhibitory receptors. ► Different KIR molecules recognize groups of class I alleles. ► Their variegated expression leads to a repertoire of NK cells with different cytotoxicities. ► Allotransplantation demonstrated that KIR can b...

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Veröffentlicht in:	Current opinion in immunology 2012-04, Vol.24 (2), p.239-245
Hauptverfasser:	Thielens, Ariane, Vivier, Eric, Romagné, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Humans Immunology Immunotherapy Life Sciences Ligands Neoplasms - immunology Neoplasms - therapy Receptors, Natural Killer Cell - immunology Receptors, Natural Killer Cell - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights ► NK cell activity is governed by balance of activating and inhibitory receptors. ► Different KIR molecules recognize groups of class I alleles. ► Their variegated expression leads to a repertoire of NK cells with different cytotoxicities. ► Allotransplantation demonstrated that KIR can be key for haematologic tumour control. ► Therapeutic approaches based on KIR blockade are currently tested in clinics.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.01.001