Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo( a )pyrene in human macrophages

Highlights ► The IgA receptor FcαRI constitutes a molecular target for environmental PAHs. ► The prototypical PAH benzo( a )pyrene induces FcαRI expression in human macrophages. ► Such a regulation occurs in an AhR-dependent manner.

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Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 2011-11, Vol.290 (1), p.89-95
Hauptverfasser:	Pinel-Marie, Marie-Laure, Louarn, Laetitia, Desmots, Sophie, Fardel, Olivier, Sparfel, Lydie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Antigens, CD - biosynthesis Aryl hydrocarbon receptor Benzo(a)pyrene Benzo(a)pyrene - toxicity Biological and medical sciences Cell Line, Tumor Cells, Cultured Emergency Environmental Pollutants Environmental Pollutants - toxicity FcαRI/CD89 gel electrophoresis Gene expression genes Humans immunity immunoglobulin A inflammation Life Sciences luciferase Macrophage Macrophages Macrophages - drug effects Macrophages - metabolism Male Medical sciences messenger RNA pollution polycyclic aromatic hydrocarbons protein binding protein synthesis Rats Rats, Sprague-Dawley Receptors, Aryl Hydrocarbon Receptors, Aryl Hydrocarbon - biosynthesis Receptors, Fc Receptors, Fc - biosynthesis RNA interference toxicity Toxicology transfection
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Beschreibung
Zusammenfassung:	Highlights ► The IgA receptor FcαRI constitutes a molecular target for environmental PAHs. ► The prototypical PAH benzo( a )pyrene induces FcαRI expression in human macrophages. ► Such a regulation occurs in an AhR-dependent manner.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2011.08.018