Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

Metal-free Michael addition initiated multicomponent oxidative cyclodehydration route to polysubstituted pyridines from 1,3-dicarbonyls

A simple metal-free, step-economic and selective access to pyridines from readily available substrates is reported, involving a flexible 4 A molecular sieves promoted Michael addition initiated domino three-component reaction between a 1,3-dicarbonyl, a Michael acceptor and a synthetic equivalent of...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2008-01 (35), p.4207-4209
Hauptverfasser: Liéby-Muller, Frédéric, Allais, Christophe, Constantieux, Thierry, Rodriguez, Jean
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Cyclization
Ketones - chemistry
Organic chemistry
Oxidation-Reduction
Pyridines - chemistry
Water - chemistry
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Zusammenfassung:A simple metal-free, step-economic and selective access to pyridines from readily available substrates is reported, involving a flexible 4 A molecular sieves promoted Michael addition initiated domino three-component reaction between a 1,3-dicarbonyl, a Michael acceptor and a synthetic equivalent of ammonia.
ISSN:1359-7345
1364-548X
DOI:10.1039/b805680c