Application of Hybrid Models to Blood Cell Production in the Bone Marrow
A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are...
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| Veröffentlicht in: | Mathematical modelling of natural phenomena 2011-01, Vol.6 (Supplement), p.2-12 |
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| container_title | Mathematical modelling of natural phenomena |
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| creator | Bessonov, N. Crauste, F. Fischer, S. Kurbatova, P. Volpert, V. |
| description | A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied. |
| doi_str_mv | 10.1051/mmnp/20116701 |
| format | Article |
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Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. 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| ispartof | Mathematical modelling of natural phenomena, 2011-01, Vol.6 (Supplement), p.2-12 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 92C37 Analysis of PDEs Biochemistry Bioinformatics Bone marrow Computer Science Erythrocytes erythropoiesis hybrid models Life Sciences Mathematical models Mathematics Proteins Quantitative Methods regulatory mechanisms |
| title | Application of Hybrid Models to Blood Cell Production in the Bone Marrow |
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