Application of Hybrid Models to Blood Cell Production in the Bone Marrow

Application of Hybrid Models to Blood Cell Production in the Bone Marrow

A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are...

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Veröffentlicht in:Mathematical modelling of natural phenomena 2011-01, Vol.6 (Supplement), p.2-12
Hauptverfasser: Bessonov, N., Crauste, F., Fischer, S., Kurbatova, P., Volpert, V.
Format: Artikel
Sprache:eng
Schlagworte:
92C37
Analysis of PDEs
Biochemistry
Bioinformatics
Bone marrow
Computer Science
Erythrocytes
erythropoiesis
hybrid models
Life Sciences
Mathematical models
Mathematics
Proteins
Quantitative Methods
regulatory mechanisms
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Beschreibung
Zusammenfassung:A hybrid model of red blood cell production, where cells are considered as discrete objects while intra-cellular proteins and extra-cellular biochemical substances are described with continuous models, is proposed. Spatial organization and regulation of red blood cell production (erythropoiesis) are investigated. Normal erythropoiesis is simulated in two dimensions, and the influence on the output of the model of some parameters involved in cell fate (differentiation, self-renewal, and death by apoptosis) is studied.
ISSN:0973-5348
1760-6101
DOI:10.1051/mmnp/20116701