The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks

We investigate how scale-free (SF) and Erdős–Rényi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold dynamics. In agreement with Oikonomou and Cluzel (2006) we find that networks with SF in topologies, that is SF topolog...

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Veröffentlicht in:Journal of theoretical biology 2010-11, Vol.267 (1), p.48-61
Hauptverfasser: Greenbury, Sam F., Johnston, Iain G., Smith, Matthew A., Doye, Jonathan P.K., Louis, Ard A.
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Sprache:eng
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