Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes
Aim Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea. Research design and methods We performed a randomized, prospective, double-blind, and parallel group design implemented in geriatric nursing homes in Catanzaro, Italy, fro...
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Veröffentlicht in: | European journal of clinical pharmacology 2010-02, Vol.66 (2), p.137-144 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Aim Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea. Research design and methods We performed a randomized, prospective, double-blind, and parallel group design implemented in geriatric nursing homes in Catanzaro, Italy, from February 2008 to March 2009. Patients of both sexes were randomly allocated to receive either one tablet of racecadotril 100 mg every 8 h or two tablets of loperamide 2.0 mg followed by one tablet after each unformed stool, up to four tablets in any 24-h period. Patients were treated until recovery, defined as the production of two consecutive normal stools or no stool production for a period of 12 h. Results Normal stools were collected 36 ± 4 h after the beginning of racecadotril and in 63 ± 6 h from the beginning of loperamide administration (P |
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ISSN: | 0031-6970 1432-1041 |
DOI: | 10.1007/s00228-009-0751-3 |