A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides

A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides

The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in go...

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Veröffentlicht in:Organic letters 2011-06, Vol.13 (11), p.2818-2821
Hauptverfasser: Racine, Emilie, Monnier, Florian, Vors, Jean-Pierre, Taillefer, Marc
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container_end_page 2821
container_issue 11
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container_title Organic letters
container_volume 13
creator Racine, Emilie
Monnier, Florian
Vors, Jean-Pierre
Taillefer, Marc
description The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.
doi_str_mv 10.1021/ol200750p
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title A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides
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