A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides
The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in go...
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Veröffentlicht in: | Organic letters 2011-06, Vol.13 (11), p.2818-2821 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol200750p |