Regioselective Biocatalyst for Alkane Activation under Mild Conditions

Going green: Chemical methods for the hydroxylation of alkanes involve toxic, dangerous reagents and are not very selective. In a biochemical alternative route based on an artificial self‐sufficient cytochrome P450, the highly selective and efficient terminal hydroxylation of n‐alkanes is possible u...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2011-02, Vol.50 (9), p.2075-2079
Hauptverfasser:	Bordeaux, Mélanie, Galarneau, Anne, Fajula, François, Drone, Jullien
Format:	Artikel
Sprache:	eng
Schlagworte:	alkane activation Alkanes - chemistry Binding Sites Biocatalysis Biochemistry Biochemistry, Molecular Biology Catalysis Chemical Sciences Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism cytochromes Hydroxylation Life Sciences Material chemistry NADP - chemistry Oxidation-Reduction oxidative biocatalysis Protein Engineering Protein Structure, Tertiary Spectrophotometry, Ultraviolet Stereoisomerism sustainable chemistry
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Beschreibung
Zusammenfassung:	Going green: Chemical methods for the hydroxylation of alkanes involve toxic, dangerous reagents and are not very selective. In a biochemical alternative route based on an artificial self‐sufficient cytochrome P450, the highly selective and efficient terminal hydroxylation of n‐alkanes is possible under mild conditions (see scheme; NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate (NADP+)).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201005597