Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma

BackgroundIn conjunctival melanoma, little is known about the tumour biology and protein-expression patterns. In this study, the authors analysed the expression of the antiapoptotic oncoprotein B cell leukaemia/lymphoma-2 protein (Bcl-2), the tumour-suppressor phosphatase and tensin homologue delete...

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Veröffentlicht in:	British journal of ophthalmology 2011-06, Vol.95 (6), p.853-858
Hauptverfasser:	Westekemper, Henrike, Karimi, Sara, Süsskind, Daniela, Anastassiou, Gerasimos, Freistühler, Michael, Steuhl, Klaus-Peter, Bornfeld, Norbert, Schmid, Kurt-Werner, Grabellus, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Bcl-2 Biological and medical sciences Chemotherapy conjunctiva Conjunctival Neoplasms - metabolism Dermatology Diagnosis, Differential Female HSP 90 HSP90 Heat-Shock Proteins - metabolism Humans Immunohistochemistry Male Medical prognosis Medical sciences melanocytes Melanoma Melanoma - metabolism Metastasis Middle Aged Miscellaneous Mutation neoplasia Neoplasm Proteins - metabolism Nevus, Pigmented - metabolism ocular surface Ophthalmology pathology Phosphatase Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism PTEN PTEN Phosphohydrolase - metabolism Reproducibility of Results Skin cancer Tumors Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	BackgroundIn conjunctival melanoma, little is known about the tumour biology and protein-expression patterns. In this study, the authors analysed the expression of the antiapoptotic oncoprotein B cell leukaemia/lymphoma-2 protein (Bcl-2), the tumour-suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN), and the heat-shock-protein HSP-90 in conjunctival melanoma (CoM) and conjunctival nevi (CoN) by immunohistochemistry (IHC).Material and methodsIHC was performed on 70 samples of CoM and 12 samples of CoN. Expression patterns between the diagnosis groups were compared. A receiver operating characteristic analysis was performed to determine the diagnostic value of the antigens.ResultsHSP-90 (p
ISSN:	0007-1161 1468-2079
DOI:	10.1136/bjo.2010.183939