No efficacy of processed Fabuless (Olibra) in suppressing appetite or food intake

Background/Objectives: To investigate the feasibility of Fabuless (previously called Olibra and Reducal) as a food ingredient for food intake and appetite reduction, by assessing the effects of food processing on efficacy. Subjects/Methods: In total, 24 healthy volunteers (16 female, 8 male; age: 18–43 years; body mass index: 18–37 kg/m2) took part in a randomized, placebo-controlled, double-blinded, cross-over trial. Yoghurt-based meal replacement drinks (containing processed or unprocessed Fabuless, or a control fat) were followed by an ad libitum lunch and evening meal (dinner). Key outcome measures were energy intake and self-reported appetite ratings. Results: Compared with control, only unprocessed Fabuless reduced subsequent energy intake, although only during dinner (P