Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are repo...

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Veröffentlicht in:	Tetrahedron 2009-12, Vol.65 (50), p.10424-10429
Hauptverfasser:	Festa, Carmen, De Marino, Simona, Sepe, Valentina, Monti, Maria Chiara, Luciano, Paolo, D'Auria, Maria Valeria, Débitus, Cecile, Bucci, Mariarosaria, Vellecco, Valentina, Zampella, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Chemistry Exact sciences and technology General pharmacology Life Sciences Marine Medical sciences Organic chemistry Peptides Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Preparations and properties Theonella swinhoei
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Zusammenfassung:	Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are reported. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2009.10.026