Expression of MCSP and PRAME in conjunctival melanoma

BackgroundTo analyse the expression of melanoma chondroitin sulfate proteoglycan (MCSP) and the preferentially expressed antigen of melanoma (PRAME) in conjunctival melanoma (CoM), lymph node (LN) metastases of cutaneous melanoma (CM) and conjunctival nevi (CoN) by immunohistology.MethodsImmunohisto...

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Veröffentlicht in:	British journal of ophthalmology 2010-10, Vol.94 (10), p.1322-1327
Hauptverfasser:	Westekemper, Henrike, Karimi, Sara, Süsskind, Daniela, Anastassiou, Gerasimos, Freistühler, Michael, Meller, Daniel, Zeschnigk, Michael, Steuhl, Klaus-Peter, Bornfeld, Norbert, Schmid, Kurt-Werner, Grabellus, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Neoplasm - metabolism Biological and medical sciences Cancer Chondroitin Sulfate Proteoglycans - metabolism conjunctiva Conjunctival Neoplasms - metabolism Conjunctival Neoplasms - mortality Dermatology diagnostic tests/investigation Female Humans Immunohistochemistry Kaplan-Meier Estimate Lymphatic Metastasis Male MCSP Medical prognosis Medical sciences Melanoma Melanoma - metabolism Melanoma - mortality Melanoma - secondary Membrane Proteins - metabolism Metastasis Middle Aged Miscellaneous neoplasia Neoplasm Recurrence, Local - metabolism Nevus of Ota - metabolism Nevus of Ota - mortality Observer Variation Ophthalmology pathology PRAME ROC Curve Skin Neoplasms - metabolism Skin Neoplasms - mortality Tumors Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	BackgroundTo analyse the expression of melanoma chondroitin sulfate proteoglycan (MCSP) and the preferentially expressed antigen of melanoma (PRAME) in conjunctival melanoma (CoM), lymph node (LN) metastases of cutaneous melanoma (CM) and conjunctival nevi (CoN) by immunohistology.MethodsImmunohistology was performed in 70 samples of CoM, 25 of LN metastases of CM and 12 of CoN, and assessed by an immunoreactive score (0–12 points). Statistical analysis was performed to disclose relevant differences in the expression pattern. The diagnostic value of the markers was tested by receiver operating characteristics (ROC) analysis.ResultsMCSP and PRAME were expressed at significantly higher levels in CoM and LN metastases of CM than in CoN (p
ISSN:	0007-1161 1468-2079
DOI:	10.1136/bjo.2009.167445