Investigation of a Series of Silver-N-Heterocyclic Carbenes as Antibacterial Agents: Activity, Synergistic Effects, and Cytotoxicity

The power of silver! Silver–N‐heterocyclic carbenes (NHCs), commonly used in catalysis, exhibit high antibacterial activity. Some are efficient at low concentrations against resistant strains of S. aureus that cause major problems to public health. Due to synergistic effects, silver–NHCs can also restore the activity of ciprofloxacin against resistant S. aureus NorA at very low concentrations (see graphic).