Nationwide linkage analysis in Scotland implicates age as the critical overall determinant of mortality in ulcerative colitis

Aliment Pharmacol Ther 31, 1310–1321 Summary Background Recent data associated higher mortality with medical rather than surgical intervention in patients with ulcerative colitis who require hospitalization. Aim To examine factors influencing UC‐related mortality in Scotland. Method Using the national record linkage database 1998–2000, 3‐year mortality was determined after four admission types: colectomy‐elective or emergency; no colectomy‐elective or emergency. Results Of 1078 patients, crude 3‐year mortality rates were: colectomy elective 5.6% (n = 177) and emergency 9.0% (100); no colectomy elective 9.8% (244) and emergency 16.0% (557). Using elective colectomy as reference, multivariate analysis [OR (95% CI)] showed that admission age >50 years [OR 5.46 (2.29–11.95)], male gender [OR 1.92 (1.23–3.02)], comorbidity [OR 2.2 (1.38–3.51)], length of stay >15 days [OR 2.04 (1.08–3.84)] and prior IBD admission [OR 1.66 (1.06–2.61)] were independently related to mortality. Age was the strongest determinant. No patient