Micro-structured reactors as a tool for chiral modifier screening in gas–liquid–solid asymmetric hydrogenations
A continuous micro-structured reactor equipped with a perforated (5 μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al 2O 3 catalyst modified with chiral inductors under high hydrogen pressure (45 bar). Up to eight chiral inducto...
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| Veröffentlicht in: | Catalysis today 2007-07, Vol.125 (1), p.34-39 |
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| container_title | Catalysis today |
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| creator | Abdallah, Radwan Fumey, Bruno Meille, Valérie de Bellefon, Claude |
| description | A continuous micro-structured reactor equipped with a perforated (5
μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al
2O
3 catalyst modified with chiral inductors under high hydrogen pressure (45
bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100
μl) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported. |
| doi_str_mv | 10.1016/j.cattod.2007.01.055 |
| format | Article |
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μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al
2O
3 catalyst modified with chiral inductors under high hydrogen pressure (45
bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100
μl) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported.</description><identifier>ISSN: 0920-5861</identifier><identifier>EISSN: 1873-4308</identifier><identifier>DOI: 10.1016/j.cattod.2007.01.055</identifier><identifier>CODEN: CATTEA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Applied sciences ; Asymmetric hydrogenation ; Catalysis ; Chemical engineering ; Chemistry ; Chiral modifiers ; Ethylpyruvate ; Exact sciences and technology ; General and physical chemistry ; Heterogeneous catalysis ; High throughput screening ; Ligand library ; Micro-reactor ; Reactors ; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</subject><ispartof>Catalysis today, 2007-07, Vol.125 (1), p.34-39</ispartof><rights>2007 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-29c10f2fd543bc324b8dbd18c615233489ed5a01d80a5a5a4e0118fc2f3d94773</citedby><cites>FETCH-LOGICAL-c370t-29c10f2fd543bc324b8dbd18c615233489ed5a01d80a5a5a4e0118fc2f3d94773</cites><orcidid>0000-0003-2258-9656</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cattod.2007.01.055$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,309,310,314,780,784,789,790,885,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18955891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00532923$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdallah, Radwan</creatorcontrib><creatorcontrib>Fumey, Bruno</creatorcontrib><creatorcontrib>Meille, Valérie</creatorcontrib><creatorcontrib>de Bellefon, Claude</creatorcontrib><title>Micro-structured reactors as a tool for chiral modifier screening in gas–liquid–solid asymmetric hydrogenations</title><title>Catalysis today</title><description>A continuous micro-structured reactor equipped with a perforated (5
μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al
2O
3 catalyst modified with chiral inductors under high hydrogen pressure (45
bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100
μl) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported.</description><subject>Applied sciences</subject><subject>Asymmetric hydrogenation</subject><subject>Catalysis</subject><subject>Chemical engineering</subject><subject>Chemistry</subject><subject>Chiral modifiers</subject><subject>Ethylpyruvate</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Heterogeneous catalysis</subject><subject>High throughput screening</subject><subject>Ligand library</subject><subject>Micro-reactor</subject><subject>Reactors</subject><subject>Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</subject><issn>0920-5861</issn><issn>1873-4308</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kM9qGzEQh0VJoU7aN-hBlx562M1IWnm1l0AITVNw6KU9C1l_7DHrVSrJAd_yDnnDPklltiS3IIEG8ftmmI-QzwxaBmx5uWutKSW6lgP0LbAWpHxHFkz1oukEqDOygIFDI9WSfSDnOe8AQKmOL0i-R5tik0s62HJI3tHkjS0xZWrqpSXGkYaYqN1iMiPdR4cBfaLZJu8nnDYUJ7ox-e_T84h_DuhqkeOIrvLH_d6XhJZujy7FjZ9MwTjlj-R9MGP2n_6_F-T37bdfN3fN6uf3HzfXq8aKHkrDB8sg8OBkJ9ZW8G6t3NoxZZdMciE6NXgnDTCnwMh6Og-MqWB5EG7o-l5ckK9z360Z9UPCvUlHHQ3qu-uVPv0BSMEHLh5ZzXZzttrIOfnwAjDQJ8l6p2fJ-iRZA9NVcsW-zNiDydaMIZnJYn5l1SClGk7tr-acr_s-Vn86W_ST9Q6Tt0W7iG8P-gei6pgZ</recordid><startdate>20070715</startdate><enddate>20070715</enddate><creator>Abdallah, Radwan</creator><creator>Fumey, Bruno</creator><creator>Meille, Valérie</creator><creator>de Bellefon, Claude</creator><general>Elsevier B.V</general><general>Elsevier Science</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-2258-9656</orcidid></search><sort><creationdate>20070715</creationdate><title>Micro-structured reactors as a tool for chiral modifier screening in gas–liquid–solid asymmetric hydrogenations</title><author>Abdallah, Radwan ; Fumey, Bruno ; Meille, Valérie ; de Bellefon, Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-29c10f2fd543bc324b8dbd18c615233489ed5a01d80a5a5a4e0118fc2f3d94773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Applied sciences</topic><topic>Asymmetric hydrogenation</topic><topic>Catalysis</topic><topic>Chemical engineering</topic><topic>Chemistry</topic><topic>Chiral modifiers</topic><topic>Ethylpyruvate</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Heterogeneous catalysis</topic><topic>High throughput screening</topic><topic>Ligand library</topic><topic>Micro-reactor</topic><topic>Reactors</topic><topic>Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdallah, Radwan</creatorcontrib><creatorcontrib>Fumey, Bruno</creatorcontrib><creatorcontrib>Meille, Valérie</creatorcontrib><creatorcontrib>de Bellefon, Claude</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Catalysis today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdallah, Radwan</au><au>Fumey, Bruno</au><au>Meille, Valérie</au><au>de Bellefon, Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micro-structured reactors as a tool for chiral modifier screening in gas–liquid–solid asymmetric hydrogenations</atitle><jtitle>Catalysis today</jtitle><date>2007-07-15</date><risdate>2007</risdate><volume>125</volume><issue>1</issue><spage>34</spage><epage>39</epage><pages>34-39</pages><issn>0920-5861</issn><eissn>1873-4308</eissn><coden>CATTEA</coden><abstract>A continuous micro-structured reactor equipped with a perforated (5
μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al
2O
3 catalyst modified with chiral inductors under high hydrogen pressure (45
bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100
μl) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.cattod.2007.01.055</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2258-9656</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-5861 |
| ispartof | Catalysis today, 2007-07, Vol.125 (1), p.34-39 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Applied sciences Asymmetric hydrogenation Catalysis Chemical engineering Chemistry Chiral modifiers Ethylpyruvate Exact sciences and technology General and physical chemistry Heterogeneous catalysis High throughput screening Ligand library Micro-reactor Reactors Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry |
| title | Micro-structured reactors as a tool for chiral modifier screening in gas–liquid–solid asymmetric hydrogenations |
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