Micro-structured reactors as a tool for chiral modifier screening in gas–liquid–solid asymmetric hydrogenations
A continuous micro-structured reactor equipped with a perforated (5 μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al 2O 3 catalyst modified with chiral inductors under high hydrogen pressure (45 bar). Up to eight chiral inducto...
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Veröffentlicht in: | Catalysis today 2007-07, Vol.125 (1), p.34-39 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A continuous micro-structured reactor equipped with a perforated (5
μm) membrane is used for the investigation of the gas–liquid–solid asymmetric hydrogenation of ethylpyruvate on a Pt/γ-Al
2O
3 catalyst modified with chiral inductors under high hydrogen pressure (45
bar). Up to eight chiral inductors have been evaluated, the best enantioselectivity (63%) being obtained with cinchonidine. The very low reaction volume (100
μl) offers short operating time. Solvent effect, deactivation studies and the effect of modifier leaching are also reported. |
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ISSN: | 0920-5861 1873-4308 |
DOI: | 10.1016/j.cattod.2007.01.055 |