Lys-gamma3-MSH: A global regulator of hormone sensitive lipase activity?

Gamma-melanocyte stimulating hormone (γ-MSH) is a peptide derived from the ACTH precursor, pro-opiomelanocortin (POMC), and belongs to a family of peptides called the melanocortins that also comprises alpha- and beta-MSH. Although conserved in tetrapods, the biological role of γ-MSH remains largely...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular and cellular endocrinology 2009-03, Vol.300 (1-2), p.71-76
Hauptverfasser: Bicknell, Katrina A., Harmer, Stephen C., Yiangson, Stephanie, Lockwood, Wendy, Bicknell, Andrew B.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Gamma-melanocyte stimulating hormone (γ-MSH) is a peptide derived from the ACTH precursor, pro-opiomelanocortin (POMC), and belongs to a family of peptides called the melanocortins that also comprises alpha- and beta-MSH. Although conserved in tetrapods, the biological role of γ-MSH remains largely undefined. It has been demonstrated previously that γ-MSH is involved in the regulating the activity of hormone sensitive lipase (HSL) activity in the adrenal and more recently, in the adipocyte. It has been shown also to have effects on the cardiovascular and renal systems. This short review will provide a brief overview of the role of γ-MSH in the adrenal and the more recent report that it can also regulate HSL function in the adipocyte. We also present some preliminary data purporting a direct role for Lys-γ3-MSH in the regulation of HSL phosphorylation in the heart. Taken together these data suggest that γ-MSH peptides might play a more widespread role in lipid and cholesterol utilization.
ISSN:0303-7207
1872-8057
0303-7207
DOI:10.1016/j.mce.2008.09.032