Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin‐Specific MKLP‐2 Inhibitor

Relocation, relocation: Inactivation of the mitotic kinesin MKLP‐2 by a specific small‐molecule inhibitor (1) leads to failure in the recruitment of the chromosome passenger protein (survivin, red) to the central spindle (microtubules, green) during anaphase chromosome segregation (DNA, blue).

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-10, Vol.49 (44), p.8228-8231
Hauptverfasser:	Tcherniuk, Sergey, Skoufias, Dimitrios A, Labriere, Christophe, Rath, Oliver, Gueritte, Françoise, Guillou, Catherine, Kozielski, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylonitrile - analogs & derivatives Acrylonitrile - pharmacology antimitotics antitumor agents Aurora Kinase B Aurora Kinases Centromere Chemical Sciences cytokinesis Indoles - pharmacology Inhibitor of Apoptosis Proteins inhibitors kinesin Kinesin - antagonists & inhibitors Microtubule-Associated Proteins - metabolism Organic chemistry Protein-Serine-Threonine Kinases - metabolism Spindle Apparatus
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Beschreibung
Zusammenfassung:	Relocation, relocation: Inactivation of the mitotic kinesin MKLP‐2 by a specific small‐molecule inhibitor (1) leads to failure in the recruitment of the chromosome passenger protein (survivin, red) to the central spindle (microtubules, green) during anaphase chromosome segregation (DNA, blue).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201003254