Intrinsic variability of latency to first-spike
The assessment of the variability of neuronal spike timing is fundamental to gain understanding of latency coding. Based on recent mathematical results, we investigate theoretically the impact of channel noise on latency variability. For large numbers of ion channels, we derive the asymptotic distri...
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| Veröffentlicht in: | Biological cybernetics 2010-07, Vol.103 (1), p.43-56 |
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| container_title | Biological cybernetics |
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| creator | Gilles, Wainrib Michèle, Thieullen Khashayar, Pakdaman |
| description | The assessment of the variability of neuronal spike timing is fundamental to gain understanding of latency coding. Based on recent mathematical results, we investigate theoretically the impact of channel noise on latency variability. For large numbers of ion channels, we derive the asymptotic distribution of latency, together with an explicit expression for its variance. Consequences in terms of information processing are studied with Fisher information in the Morris-Lecar model. A competition between sensitivity to input and precision is responsible for favoring two distinct regimes of latencies. |
| doi_str_mv | 10.1007/s00422-010-0384-8 |
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Based on recent mathematical results, we investigate theoretically the impact of channel noise on latency variability. For large numbers of ion channels, we derive the asymptotic distribution of latency, together with an explicit expression for its variance. Consequences in terms of information processing are studied with Fisher information in the Morris-Lecar model. 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| ispartof | Biological cybernetics, 2010-07, Vol.103 (1), p.43-56 |
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| subjects | Action Potentials - physiology Animals Assessments Asymptotic properties Bioinformatics Biology Biomedical and Life Sciences Biomedicine Cell Membrane - physiology Central Nervous System - physiology Channel noise Complex Systems Computer Appl. in Life Sciences Cybernetics Fisher information Gain Humans Ion Channel Gating - physiology Ion channels Ions Latency coding Life Sciences Mathematical models Morris-Lecar model Neurobiology Neurons Neurons - physiology Neurosciences Original Paper Other Reaction Time - physiology Spikes Synaptic Transmission - physiology |
| title | Intrinsic variability of latency to first-spike |
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