Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants, each of small effect. Identifying whether risk variants map to specific molecular pathways is potentially biologically informative. We report a molecular pat...

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Veröffentlicht in:	Molecular psychiatry 2011-03, Vol.16 (3), p.286-292
Hauptverfasser:	O'Dushlaine, C, Kenny, E, Heron, E, Donohoe, G, Gill, M, Morris, D, Corvin, A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/79 631/92/1643 692/699/476/1333 692/699/476/1799 Adult and adolescent clinical studies Analysis Autism Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - genetics Bipolar disorders Care and treatment Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules, Neuronal - genetics Cell signaling Consortia Datasets Development and progression Disease susceptibility Female GABA Genes Genetic aspects Genetic diversity Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Health aspects Health risk assessment Humans Male Medical sciences Medicine Medicine & Public Health Membrane Proteins - genetics Mental disorders Mood disorders Nerve Tissue Proteins - genetics Neurosciences original-article Pharmacotherapy Phenotypes Physiological aspects Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Risk factors Schizophrenia Schizophrenia - genetics Signal Transduction - genetics Single-nucleotide polymorphism
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Zusammenfassung:	Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants, each of small effect. Identifying whether risk variants map to specific molecular pathways is potentially biologically informative. We report a molecular pathway analysis using the single-nucleotide polymorphism (SNP) ratio test, which compares the ratio of nominally significant ( P
ISSN:	1359-4184 1476-5578
DOI:	10.1038/mp.2010.7