TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells

Gliomas are one of the most malignant cancers. The molecular bases regulating the onset of such tumors are still poorly understood. The translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is a mitochondrial permeability transition (MPT)-pore protein robustly e...

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Veröffentlicht in:	Biochimica et biophysica acta 2008-02, Vol.1782 (2), p.118-125
Hauptverfasser:	Rechichi, Mariarosa, Salvetti, Alessandra, Chelli, Beatrice, Costa, Barbara, Da Pozzo, Eleonora, Spinetti, Francesca, Lena, Annalisa, Evangelista, Monica, Rainaldi, Giuseppe, Martini, Claudia, Gremigni, Vittorio, Rossi, Leonardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Cell Movement - genetics Cell Proliferation Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Glioma Glioma - genetics Glioma - pathology Isoquinolines - pharmacology Ligand-binding Ligands Neoplasm Invasiveness Over-expression Peripheral-type benzodiazepine receptor Proliferation Rats Receptors, GABA-A - genetics Receptors, GABA-A - metabolism Receptors, GABA-A - physiology Transfection Tumor Cells, Cultured Tumor invasiveness Up-Regulation
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