Iron-Catalyzed Alkylations of Aromatic Grignard Reagents

Any old iron: Two efficient iron‐catalyzed cross‐coupling reactions between aryl Grignard reagents and alkyl bromides were developed that are suitable for large‐scale applications. The first procedure uses iron acetylacetonate and involves a cooperative effect between the two ligands N,N,N′,N′‐tetra...

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Veröffentlicht in:	Angewandte Chemie International Edition 2007-01, Vol.46 (23), p.4364-4366
Hauptverfasser:	Cahiez, Gérard, Habiak, Vanessa, Duplais, Christophe, Moyeux, Alban
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Catalysis cross‒coupling Ferric Compounds - chemistry Grignard reagents homogeneous catalysis Hydrocarbons, Halogenated - chemical synthesis Hydrocarbons, Halogenated - chemistry Indicators and Reagents - chemistry iron Molecular Structure Organometallic Compounds - chemistry Stereoisomerism sustainable chemistry
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Beschreibung
Zusammenfassung:	Any old iron: Two efficient iron‐catalyzed cross‐coupling reactions between aryl Grignard reagents and alkyl bromides were developed that are suitable for large‐scale applications. The first procedure uses iron acetylacetonate and involves a cooperative effect between the two ligands N,N,N′,N′‐tetramethylethylenediamine (TMEDA) and hexamethylenetetraamine (HMTA), while the second procedure uses [(FeCl3)2(tmeda)3] as catalyst.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200700742