Synthesis of unsymmetrical spin-labelled bolaamphiphiles

Synthesis of unsymmetrical spin-labelled bolaamphiphiles

This work presents the efficient synthesis of a novel spin-labelled bolaamphiphile bearing sugar and cationic polar heads. Preliminary ESR studies were conduced both in CH 2Cl 2 and water and have confirmed that this methodology can be used to study the transversal rotation (flip–flop) dynamic of me...

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Veröffentlicht in:Tetrahedron letters 2008-08, Vol.49 (32), p.4690-4692
Hauptverfasser: Berchel, Mathieu, Lemiègre, Loïc, Jeftić, Jelena, Benvegnu, Thierry
Format: Artikel
Sprache:eng
Schlagworte:
Archaea
Bolaamphiphile
Chemical Sciences
ESR
Nitroxide
Organic chemistry
Synthesis
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Beschreibung
Zusammenfassung:This work presents the efficient synthesis of a novel spin-labelled bolaamphiphile bearing sugar and cationic polar heads. Preliminary ESR studies were conduced both in CH 2Cl 2 and water and have confirmed that this methodology can be used to study the transversal rotation (flip–flop) dynamic of membrane involving such bolaamphiphiles.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.05.125