Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids
Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(γ-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small ves...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2009-01, Vol.48 (14), p.2572-2575 |
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| container_title | Angewandte Chemie (International ed.) |
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| creator | Schatz, Christophe Louguet, Stéphanie Le Meins, Jean-François Lecommandoux, Sébastien |
| description | Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(γ-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small vesicles (see picture) suggests the possibility of a new generation of drug- and gene-delivery systems whose structure mimics that of viruses. |
| doi_str_mv | 10.1002/anie.200805895 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2009-01, Vol.48 (14), p.2572-2575 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Azides - chemical synthesis Azides - chemistry Capsid - chemistry Chemical Sciences click chemistry Dextrans - chemical synthesis Dextrans - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Gene Transfer Techniques Particle Size Peptides - chemical synthesis Peptides - chemistry Polyglutamic Acid - analogs & derivatives Polyglutamic Acid - chemical synthesis Polyglutamic Acid - chemistry Polymers Polymers - chemical synthesis Polymers - chemistry polymersomes polypeptides polysaccharides Polysaccharides - chemical synthesis Polysaccharides - chemistry self‐assembly Viruses - chemistry |
| title | Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids |
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