Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(γ-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small ves...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-01, Vol.48 (14), p.2572-2575
Hauptverfasser:	Schatz, Christophe, Louguet, Stéphanie, Le Meins, Jean-François, Lecommandoux, Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Azides - chemical synthesis Azides - chemistry Capsid - chemistry Chemical Sciences click chemistry Dextrans - chemical synthesis Dextrans - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Gene Transfer Techniques Particle Size Peptides - chemical synthesis Peptides - chemistry Polyglutamic Acid - analogs & derivatives Polyglutamic Acid - chemical synthesis Polyglutamic Acid - chemistry Polymers Polymers - chemical synthesis Polymers - chemistry polymersomes polypeptides polysaccharides Polysaccharides - chemical synthesis Polysaccharides - chemistry self‐assembly Viruses - chemistry
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Beschreibung
Zusammenfassung:	Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(γ-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small vesicles (see picture) suggests the possibility of a new generation of drug- and gene-delivery systems whose structure mimics that of viruses.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200805895