NIS-promoted guanylation of amines
An efficient NIS-promoted guanylation reaction is described. This procedure allows the guanylation of primary and secondary amines through the reaction with di-Boc-thiourea and di-Boc- S-methylisothiourea, respectively. We demonstrated that the use of NIS compares favorably with existing methods and...
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Veröffentlicht in: | Tetrahedron letters 2009-04, Vol.50 (13), p.1463-1465 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | An efficient NIS-promoted guanylation reaction is described. This procedure allows the guanylation of primary and secondary amines through the reaction with di-Boc-thiourea and di-Boc-
S-methylisothiourea, respectively. We demonstrated that the use of NIS compares favorably with existing methods and is an attractive alternative to heavy metal or Mukayama’s reagent activation. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2009.01.073 |