Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-08, Vol.71 (8), p.1451-1454
Hauptverfasser:	Appenzeller, Jérôme, Mihci, Ghezala, Martin, Marie-Thérèse, Gallard, Jean-François, Menou, Jean-Louis, Boury-Esnault, Nicole, Hooper, John, Petek, Sylvain, Chevalley, Severine, Valentin, Alexis, Zaparucha, Anne, Al-Mourabit, Ali, Debitus, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	Agelas agelasine Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals anticarcinogenic activity Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology antiprotozoal activity Biological and medical sciences Chemical Sciences chemical structure Chromatography, High Pressure Liquid cultured cells cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoid alkaloids General pharmacology humans Marine Mass Spectrometry Medical sciences Molecular Structure Organic chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Porifera spectral analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np800212g