Cyclic AMP stimulates the protein tyrosine kinase activity of Acinetobacter calcoaceticus

Cyclic AMP stimulates the protein tyrosine kinase activity of Acinetobacter calcoaceticus

Abstract The protein tyrosine kinase activity of Acinetobacter calcoaceticus was analyzed in vitro through the specific phosphorylation of an endogenous protein which is modified exclusively at tyrosine residues. A strong stimulation of this activity by cyclic AMP was observed. This finding represen...

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Veröffentlicht in:FEMS microbiology letters 1997-07, Vol.152 (2), p.333-337
Hauptverfasser: Grangeasse, Christophe, Vaganay, Elisabeth, Doublet, Patricia, Riberty, Mylène, Cozzone, Alain J, Duclos, Bertrand
Format: Artikel
Sprache:eng
Schlagworte:
Acinetobacter calcoaceticus
Biochemistry, Molecular Biology
Cyclic AMP
Eukaryotes
Kinases
Life Sciences
Microbiology
Nucleotides
Phosphorylation
Prokaryotes
Protein tyrosine kinase
Proteins
Tyrosine
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Zusammenfassung:Abstract The protein tyrosine kinase activity of Acinetobacter calcoaceticus was analyzed in vitro through the specific phosphorylation of an endogenous protein which is modified exclusively at tyrosine residues. A strong stimulation of this activity by cyclic AMP was observed. This finding represents the first example of a protein tyrosine kinase, in prokaryotes as well as in eukaryotes, whose functioning is cyclic nucleotide-dependent.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1997.tb10448.x