A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe th...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-06, Vol.296 (5575), p.2046-2049
Hauptverfasser:	Peier, Andrea M., Reeve, Alison J., Andersson, David A., Moqrich, Aziz, Earley, Taryn J., Hergarden, Anne C., Story, Gina M., Colley, Sian, Hogenesch, John B., McIntyre, Peter, Bevan, Stuart, Patapoutian, Ardem
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Animals, Newborn Biological and medical sciences Blotting, Northern Capsaicin - analogs & derivatives Capsaicin - pharmacology Cation Transport Proteins Cell Line Cells, Cultured Cellular Biology CHO Cells Cloning, Molecular Complementary DNA Cricetinae Electric current Epidermis - cytology Epidermis - innervation Epidermis - metabolism Fundamental and applied biological sciences. Psychology Ganglia, Spinal - metabolism Genomics Heat Hot Temperature Humans In Situ Hybridization Ion Channels - chemistry Ion Channels - genetics Ion Channels - metabolism Keratinocytes Keratinocytes - metabolism Life Sciences Membrane Potentials Mice Molecular Sequence Data Nerve Endings - physiology Neurons Neurons - physiology Patch-Clamp Techniques Receptors RNA, Messenger - genetics RNA, Messenger - metabolism Ruthenium Red - pharmacology Signal Transduction Skin Spinal Cord - metabolism Temperature TRPC cation channels TRPV Cation Channels TRPV3 protein Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Beschreibung
Zusammenfassung:	Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1073140