Synthesis of new oligosaccharidyl-thio-β-cyclodextrins (CDS): a novel family of potent drug-targetting vectors

Six potential carriers incorporating one or more thio-D-galactosyl residue(s) linked to β-cyclodextrin as complexing tool, were synthesized and evaluated in vitro for their specific recognition towards a cell wall galactose specific lectin (KbCWL). The inhibition of yeast flocculation by the compounds 5–10 was compared to reference compounds as, p-nitrophenyl-galactose or disaccharides containing an α or β-galactose non reducing terminal unit. Among the tested molecules, the heptakis galactosyl-CD derivatives were found the most efficient compounds. Graphic