Convenient access to bis-indole alkaloids. Application to the synthesis of topsentins
Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles. [Display omitted]
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Veröffentlicht in: | Tetrahedron 2008-06, Vol.64 (25), p.5904-5914 |
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container_title | Tetrahedron |
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creator | Mal, Sajal K. Bohé, Luis Achab, Saïd |
description | Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles.
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doi_str_mv | 10.1016/j.tet.2008.04.045 |
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[Display omitted]</description><subject>Bis-indole</subject><subject>Chemical Sciences</subject><subject>Cross-coupling</subject><subject>Imidazole</subject><subject>Organic chemistry</subject><subject>Topsentins</subject><issn>0040-4020</issn><issn>1464-5416</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KxDAUhYMoOI4-gLtuXbTe_PUHV8PgHwy4UbchTW-YjLUpTRiYt_FZfDJTRlwKBw5cznfgHkKuKRQUaHm7KyLGggHUBYgkeUIWVJQil4KWp2QBICAXwOCcXISwAwBKGV-Q97Uf9jg4HGKmjcEQsuiz1oXcDZ3vMdP9h-6960KRrcaxd0ZH54c5FLeYhcOQLLiQefv9Ff0YUpEbwiU5s7oPePXrS_L2cP-6fso3L4_P69UmN5zTmMtOc0BaMWkosLqWvNRNg7VteS3Bcls1VSU7hq0UZcNLA6wV0lYcK-S1tXxJbo69W92rcXKfejoor516Wm3UfANgjZAV3dOUpcesmXwIE9o_gIKaR1Q7lUZU84gKRJJMzN2RwfTE3uGkgklbGezchCaqzrt_6B_02Hqg</recordid><startdate>20080616</startdate><enddate>20080616</enddate><creator>Mal, Sajal K.</creator><creator>Bohé, Luis</creator><creator>Achab, Saïd</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope></search><sort><creationdate>20080616</creationdate><title>Convenient access to bis-indole alkaloids. Application to the synthesis of topsentins</title><author>Mal, Sajal K. ; Bohé, Luis ; Achab, Saïd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-5da30e1725c10288536a99e8fb3850f3f79775d2eb546936c02b45f73e7e38ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bis-indole</topic><topic>Chemical Sciences</topic><topic>Cross-coupling</topic><topic>Imidazole</topic><topic>Organic chemistry</topic><topic>Topsentins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mal, Sajal K.</creatorcontrib><creatorcontrib>Bohé, Luis</creatorcontrib><creatorcontrib>Achab, Saïd</creatorcontrib><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Tetrahedron</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mal, Sajal K.</au><au>Bohé, Luis</au><au>Achab, Saïd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Convenient access to bis-indole alkaloids. Application to the synthesis of topsentins</atitle><jtitle>Tetrahedron</jtitle><date>2008-06-16</date><risdate>2008</risdate><volume>64</volume><issue>25</issue><spage>5904</spage><epage>5914</epage><pages>5904-5914</pages><issn>0040-4020</issn><eissn>1464-5416</eissn><abstract>Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles.
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subjects | Bis-indole Chemical Sciences Cross-coupling Imidazole Organic chemistry Topsentins |
title | Convenient access to bis-indole alkaloids. Application to the synthesis of topsentins |
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