Convenient access to bis-indole alkaloids. Application to the synthesis of topsentins

Convenient access to bis-indole alkaloids. Application to the synthesis of topsentins

Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles. [Display omitted]

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Veröffentlicht in:Tetrahedron 2008-06, Vol.64 (25), p.5904-5914
Hauptverfasser: Mal, Sajal K., Bohé, Luis, Achab, Saïd
Format: Artikel
Sprache:eng
Schlagworte:
Bis-indole
Chemical Sciences
Cross-coupling
Imidazole
Organic chemistry
Topsentins
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Beschreibung
Zusammenfassung:Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2008.04.045