Zinc status and immune system relationship: a review

The essentiality of zinc for humans was first documented by Prasad in the 1960s. The main clinical manifestations associated with zinc deficiency are growth retardation, hypogonadism, diarrhea, and increased susceptibility to infectious diseases. Thus, in the past 25 yr, there was an increased inter...

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Veröffentlicht in:	Biological trace element research 2000-09, Vol.76 (3), p.193-205
Hauptverfasser:	Salgueiro, M J, Zubillaga, M, Lysionek, A, Cremaschi, G, Goldman, C G, Caro, R, De Paoli, T, Hager, A, Weill, R, Boccio, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animal models Animals Child Diarrhea domain_sdv.ida.ing domain_sdv.ida.ing.vit Food engineering Growth rate Humans Hypogonadism Immune system Immune System - physiology Immunity Infectious diseases Life Sciences Nutrient deficiency Nutritional Status Reviews Thymus Gland - metabolism Thymus Gland - physiology Zinc Zinc - metabolism
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Zusammenfassung:	The essentiality of zinc for humans was first documented by Prasad in the 1960s. The main clinical manifestations associated with zinc deficiency are growth retardation, hypogonadism, diarrhea, and increased susceptibility to infectious diseases. Thus, in the past 25 yr, there was an increased interest of researchers in studying the role of zinc in human immunity. Although mechanistic research has been carried out using animal models, there are several studies in humans with similar results. This work is an attempt to review the information available in this field to understand the important role that zinc plays in the normal development and function of the immune system.
ISSN:	0163-4984 1559-0720
DOI:	10.1385/BTER:76:3:193