A genetic programme for neuronal connectivity

What is the nature of the genetic programme that allows neurons to extend their axons and connect to other neurons with a high degree of specificity? Work on the sensory neurons of the fly has shown how the control of neuronal identity is embedded in the general developmental programme of the organi...

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Veröffentlicht in:	Trends in genetics 2000-05, Vol.16 (5), p.221-226
Hauptverfasser:	GHYSEN, A, DAMBLY-CHAUDIERE, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Axons - physiology Biological and medical sciences Cell physiology Development Biology Drosophila Drosophila - genetics Drosophila - growth & development Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Life Sciences Molecular and cellular biology Mutation Neurons Neurons - physiology Neurons, Afferent Neurons, Afferent - physiology Neurotransmission Sense Organs Sense Organs - growth & development
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Beschreibung
Zusammenfassung:	What is the nature of the genetic programme that allows neurons to extend their axons and connect to other neurons with a high degree of specificity? Work on the sensory neurons of the fly has shown how the control of neuronal identity is embedded in the general developmental programme of the organism. The ongoing analysis of pathfinding mutants suggests plausible mechanisms for the translation of neuronal identity into axonal behaviour.
ISSN:	0168-9525
DOI:	10.1016/S0168-9525(99)01969-1