β-Catenin regulates P-cadherin expression in mammary basal epithelial cells

P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We sh...

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Veröffentlicht in:FEBS letters 2007-03, Vol.581 (5), p.831-836
Hauptverfasser: Faraldo, Marisa M., Teulière, Jérôme, Deugnier, Marie-Ange, Birchmeier, Walter, Huelsken, Joerg, Thiery, Jean Paul, Cano, Amparo, Glukhova, Marina A.
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Sprache:eng
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Zusammenfassung:P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We show that in basal mammary epithelial cells, β-catenin is associated with the P-cadherin promoter and activates its expression independently of LEF/TCF in a cell-type specific manner. Down-regulation of endogenous β-catenin levels by RNA interference technique inhibited P-cadherin promoter activity. In vivo, in skin and mammary gland of mutant mice, activation of β-catenin signalling correlates with up-regulation of P-cadherin expression. These data suggest that β-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2007.01.053