From isocyanides to trichloropyruvamides: application to a new preparation of oxamide derivatives

From isocyanides to trichloropyruvamides: application to a new preparation of oxamide derivatives

[Display omitted] Isocyanides react readily with trichloroacetic acid anhydride forming stable hydrates of trichloropyruvamides. These compounds are valuable intermediates for obtaining oxamides by reaction with TMSCl/NEt 3 followed by addition of an amine.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2004-10, Vol.45 (43), p.8047-8048
Hauptverfasser: El Kaim, Laurent, Gaultier, Laetitia, Grimaud, Laurence, Vieu, Emilie
Format: Artikel
Sprache:eng
Schlagworte:
Amide
Chemical Sciences
Isocyanides
Organic chemistry
Pyruvamide
Trichloromethyl
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Beschreibung
Zusammenfassung:[Display omitted] Isocyanides react readily with trichloroacetic acid anhydride forming stable hydrates of trichloropyruvamides. These compounds are valuable intermediates for obtaining oxamides by reaction with TMSCl/NEt 3 followed by addition of an amine.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.08.169