Conditions of wound healing and cutaneous growth affect metabolic performance of skin following plastic surgery

ABSTRACT The mechanical and structural properties of skin subjected to expansion have been widely investigated in the context of plastic surgery. To determine the actual metabolic state of skin following skin expander placement, we determined the basic biochemical parameters for various conditions of postsurgical wound healing and cutaneous growth. Studying, for the first time, comprehensive metabolic profiles (“metabolomics”) of the skin in a minipig model, we found that the lactate/alanine ratios were significantly increased (p