Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection

Host resistance to Trypanosoma cruzi infection depends on a type 1 response characterized by a strong production of IL-12 and IFN-gamma. Amplifying this response through CD40 triggering results in control of parasitemia. Two newly synthesized molecules (

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2007-06, Vol.178 (11), p.6700-6704
Hauptverfasser:	Habib, Mohammed, Noval Rivas, Magali, Chamekh, Mustapha, Wieckowski, Sébastien, Sun, Weimin, Bianco, Alberto, Trouche, Nathalie, Chaloin, Olivier, Dumortier, Hélène, Goldman, Michel, Guichard, Gilles, Fournel, Sylvie, Vray, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD40 CD40 Antigens - metabolism CD40 Antigens - physiology CD40 Ligand CD40 Ligand - chemical synthesis CD40 Ligand - deficiency CD40 Ligand - genetics CD40 Ligand - physiology Cell Line Cells, Cultured Cellular Biology Chagas Disease Chagas Disease - immunology Chagas Disease - metabolism Chagas Disease - prevention & control Interferon Type II Interferon-gamma - biosynthesis Life Sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Molecular Mimicry Molecular Mimicry - immunology Parasitemia Parasitemia - immunology Parasitemia - metabolism Parasitemia - prevention & control T-Lymphocyte Subsets T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Trypanosoma cruzi Trypanosoma cruzi - immunology
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Beschreibung
Zusammenfassung:	Host resistance to Trypanosoma cruzi infection depends on a type 1 response characterized by a strong production of IL-12 and IFN-gamma. Amplifying this response through CD40 triggering results in control of parasitemia. Two newly synthesized molecules (
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.178.11.6700