Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases

Sphingolipids is the collective term ascribed to components of the sphingomyelin cycle. Modulation of the cellular levels of individual sphingolipids can induce a diverse range of cellular responses including apoptosis, proliferation, and cell cycle arrest. We present data showing that rhabdomyosarc...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-01, Vol.67 (2), p.756-764
Hauptverfasser:	Phillips, Darren C, Martin, Sophie, Doyle, Belinda T, Houghton, Janet A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - metabolism Biochemistry, Molecular Biology Caspases - metabolism Cell Line, Tumor Cellular Biology Cytochromes c - metabolism Dose-Response Relationship, Drug Humans Life Sciences Membrane Potentials - drug effects Membrane Potentials - physiology Mice Mitochondria - drug effects Mitochondria - enzymology Mitochondria - metabolism Mitochondrial Membranes - drug effects Mitochondrial Membranes - physiology Molecular biology Reactive Oxygen Species - metabolism Rhabdomyosarcoma, Alveolar - drug therapy Rhabdomyosarcoma, Alveolar - metabolism Rhabdomyosarcoma, Alveolar - pathology Rhabdomyosarcoma, Embryonal - drug therapy Rhabdomyosarcoma, Embryonal - metabolism Rhabdomyosarcoma, Embryonal - pathology Signal Transduction - drug effects Sphingosine - metabolism Sphingosine - pharmacology Stereoisomerism
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