Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents

Peptide deformylase was discovered 30 years ago, but as a result of its unusually unstable activity it was not fully characterized until very recently. The aim of this paper is to review the many recent data concerning this enzyme and to try to assess its potential as a target for future antimicrobi...

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Veröffentlicht in:	Molecular microbiology 2000-06, Vol.36 (6), p.1197-1205
Hauptverfasser:	Giglione, Carmela, Pierre, Michèle, Meinnel, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases Aminopeptidases Aminopeptidases - antagonists & inhibitors Aminopeptidases - chemistry Aminopeptidases - physiology Animals Anti-Infective Agents Anti-Infective Agents - pharmacology Enzyme Inhibitors Enzyme Inhibitors - pharmacology Humans Life Sciences Vegetal Biology
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Beschreibung
Zusammenfassung:	Peptide deformylase was discovered 30 years ago, but as a result of its unusually unstable activity it was not fully characterized until very recently. The aim of this paper is to review the many recent data concerning this enzyme and to try to assess its potential as a target for future antimicrobial drugs.
ISSN:	0950-382X 1365-2958
DOI:	10.1046/j.1365-2958.2000.01908.x