Total Synthesis of Ecteinascidin 743
A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.
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| Veröffentlicht in: | Journal of the American Chemical Society 2006-01, Vol.128 (1), p.87-89 |
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| container_end_page | 89 |
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| container_issue | 1 |
| container_start_page | 87 |
| container_title | Journal of the American Chemical Society |
| container_volume | 128 |
| creator | Chen, Jinchun Chen, Xiaochuan Bois-Choussy, Michèle Zhu, Jieping |
| description | A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%. |
| doi_str_mv | 10.1021/ja0571794 |
| format | Article |
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Drug treatments ; Preparations and properties ; Tetrahydroisoquinolines ; Urochordata - chemistry</subject><ispartof>Journal of the American Chemical Society, 2006-01, Vol.128 (1), p.87-89</ispartof><rights>Copyright © 2006 American Chemical Society</rights><rights>2006 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a415t-30007fae8d330e32a72805111571c891cca82c833786dcd3de1f3625b819f0383</citedby><cites>FETCH-LOGICAL-a415t-30007fae8d330e32a72805111571c891cca82c833786dcd3de1f3625b819f0383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ja0571794$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ja0571794$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2763,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17720270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16390134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00018872$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jinchun</creatorcontrib><creatorcontrib>Chen, Xiaochuan</creatorcontrib><creatorcontrib>Bois-Choussy, Michèle</creatorcontrib><creatorcontrib>Zhu, Jieping</creatorcontrib><title>Total Synthesis of Ecteinascidin 743</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents, Alkylating - chemical synthesis</subject><subject>Biological and medical sciences</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Chemotherapy</subject><subject>Dioxoles - chemical synthesis</subject><subject>Exact sciences and technology</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms</subject><subject>Isoquinolines - chemical synthesis</subject><subject>Medical sciences</subject><subject>Organic chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Preparations and properties</subject><subject>Tetrahydroisoquinolines</subject><subject>Urochordata - chemistry</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1PwzAMhiMEYmNw4A-gHuDAoRAnbZMd0TQYonxIK1wjL021jK6dmg6xf0-mTeuFk2X7sf36JeQS6B1QBvcLpLEAMYyOSB9iRsMYWHJM-pRSFgqZ8B45c27h04hJOCU9SPiQAo_65DqrWyyD6aZq58ZZF9RFMNatsRU6bXNbBSLi5-SkwNKZi30ckM_HcTaahOn70_PoIQ0xgrgNuT8gCjQy55wazlAwSWMA8OK0HILWKJmWnHtJuc55bqDgCYtnEoYF5ZIPyO1u7xxLtWrsEpuNqtGqyUOqtjV_AKQU7Ac6Vje1c40pDgNA1dYVdXDFs1c7drWeLU3ekXsbPHCzB_zXWBYNVtq6jhOCUSao58IdZ11rfg99bL5VIriIVfYxVenLF5Oj7FW9dXtRO7Wo103l7ftH4B-EzX-5</recordid><startdate>20060111</startdate><enddate>20060111</enddate><creator>Chen, Jinchun</creator><creator>Chen, Xiaochuan</creator><creator>Bois-Choussy, Michèle</creator><creator>Zhu, Jieping</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope></search><sort><creationdate>20060111</creationdate><title>Total Synthesis of Ecteinascidin 743</title><author>Chen, Jinchun ; Chen, Xiaochuan ; Bois-Choussy, Michèle ; Zhu, Jieping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a415t-30007fae8d330e32a72805111571c891cca82c833786dcd3de1f3625b819f0383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Alkylating - chemical synthesis</topic><topic>Biological and medical sciences</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>Chemotherapy</topic><topic>Dioxoles - chemical synthesis</topic><topic>Exact sciences and technology</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms</topic><topic>Isoquinolines - chemical synthesis</topic><topic>Medical sciences</topic><topic>Organic chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Preparations and properties</topic><topic>Tetrahydroisoquinolines</topic><topic>Urochordata - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jinchun</creatorcontrib><creatorcontrib>Chen, Xiaochuan</creatorcontrib><creatorcontrib>Bois-Choussy, Michèle</creatorcontrib><creatorcontrib>Zhu, Jieping</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jinchun</au><au>Chen, Xiaochuan</au><au>Bois-Choussy, Michèle</au><au>Zhu, Jieping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total Synthesis of Ecteinascidin 743</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. 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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antineoplastic agents Antineoplastic Agents, Alkylating - chemical synthesis Biological and medical sciences Chemical Sciences Chemistry Chemotherapy Dioxoles - chemical synthesis Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Isoquinolines - chemical synthesis Medical sciences Organic chemistry Pharmacology. Drug treatments Preparations and properties Tetrahydroisoquinolines Urochordata - chemistry |
| title | Total Synthesis of Ecteinascidin 743 |
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