Total Synthesis of Ecteinascidin 743

A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2006-01, Vol.128 (1), p.87-89
Hauptverfasser:	Chen, Jinchun, Chen, Xiaochuan, Bois-Choussy, Michèle, Zhu, Jieping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Alkylating - chemical synthesis Biological and medical sciences Chemical Sciences Chemistry Chemotherapy Dioxoles - chemical synthesis Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Isoquinolines - chemical synthesis Medical sciences Organic chemistry Pharmacology. Drug treatments Preparations and properties Tetrahydroisoquinolines Urochordata - chemistry
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Beschreibung
Zusammenfassung:	A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja0571794